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Several neural and hormonal systems are affected by substance abuse, and when it ends they are thrown into confusion. Effects can include noradrenergic hyperactivity, gamma-aminobutyric acid -benzodiazepine receptor alteration, elevated hypothalamic-pituitary-adrenal axis, and changes in the N-methyl-D-aspartate glutamate receptors.

Symptoms include visual and auditory hallucinations and delusional thinking. Other reasons for psychosis include the presence of a co-occurring mental health disorder, such as schizophrenia, or a lack of sleep due to stimulant use. Someone who is suffering from psychosis can behave erratically and become unpredictable.
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